T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes
نویسندگان
چکیده
منابع مشابه
Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
Posttranslational modification (PTM) of self-proteins has been shown to elicit clinically relevant immune responses in rheumatoid arthritis and celiac disease. Accumulating evidence suggests that recognition of modified self-proteins may also be important in type 1 diabetes. Our objective was to identify posttranslationally modified GAD65 peptides, which are recognized by subjects with type 1 d...
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Disease susceptibility for type 1 diabetes is strongly associated with the inheritance of specific HLA alleles. However, conventional allele frequency analysis can miss HLA associations because many alleles are rare. In addition, disparate alleles that have similar peptide-binding sites, or shared epitopes, can be missed. To identify the HLA shared epitopes associated with diabetes, we analyzed...
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t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
متن کاملt helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
متن کاملRecognition of HLA Class I – Restricted - Cell Epitopes in Type 1 Diabetes
Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic -cells by cytotoxic Tlymphocytes (CTLs). In humans, few -cell epitopes have been reported, thereby limiting the study of -cell–specific CTLs in type 1 diabetes. To identify additional epitopes, HLA class I peptide affinity algorithms were used to identify a panel of peptides derived from the -cell proteins i...
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ژورنال
عنوان ژورنال: Current Diabetes Reports
سال: 2015
ISSN: 1534-4827,1539-0829
DOI: 10.1007/s11892-015-0657-7